An assessment of the effects of shell cross-linked nanoparticle size, core composition, and surface PEGylation on in vivo biodistribution.

摘要: Amphiphilic core-shell nanoparticles have drawn considerable interest in biomedical applications. The precise control over their physicochemical parameters and the ability to attach various ligands within specific domains suggest shell cross-linked (SCK) may be used as multi-/polyvalent scaffolds for drug delivery. In this study, biodistribution of four SCKs, differing size, core composition, surface PEGylation, was evaluated. To facilitate in-vivo tracking positron-emitting radionuclide copper-64 used. By using microPET imaging approaches, we found that small diameter (18 nm) SCKs possessing a polystyrene showed most favorable biological behavior terms prolonged blood retention low liver accumulation. data demonstrated both which influenced SCK flexibility shape adaptability, hydrodynamic nanoparticle play important roles respective biodistributions. Surface modification with poly(ethylene glycol) (PEG) had no noticeable effects on behavior.