A randomised double‐blind phase II study of lifestyle counselling and salicylate compounds in patients with progressive prostate cancer

摘要: Purpose – Salicylate intake and lifestyle have been implicated in the aetiology of prostate cancer, but purpose this paper is to evaluate their influence on established cancer progression.Design/methodology/approach A randomised, double blind, phase II study involving 110 men whose specific antigen (PSA), had risen three consecutive values, >20 per cent over proceeding six months. Men were counselled eat less saturated fat, processed food, more fruit, vegetables legumes; exercise regularly stop smoking. They then randomised take sodium salicylate (SS) alone or SS combined with, vitamin C, copper manganese gluconates (CV247). Patients took daily, without other intervention, withdrawn if PSA doubling time (PSAdt) shortened rose from baseline.Findings Although there was no difference outcome between CV247 (21 v 19 p = 0.92), intervention slowed stopped rate progression 40 ...