A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer.

作者: Robert S. Sandler , Susan Halabi , John A. Baron , Susan Budinger , Electra Paskett

DOI: 10.1056/NEJMOA021633

关键词: Clinical trialMedicineInternal medicineAspirinAdenomaRandomizationRandomized controlled trialColonoscopyColorectal cancerGastroenterologyInterim analysis

摘要: Background Experimental studies in animals and observational studies in humans suggest that regular aspirin use may decrease the risk of colorectal adenomas, the precursors to most …

参考文章(47)
R S Sandler, Aspirin and other nonsteroidal anti-inflammatory agents in the prevention of colorectal cancer. Important advances in oncology. pp. 123- 137 ,(1996)
P. J. Cheek, P. McCullagh, J. A. Nelder, Generalized Linear Models, 2nd Edn. Applied Statistics. ,vol. 39, pp. 385- 386 ,(1990) , 10.2307/2347392
Peter McCullagh, John Ashworth Nelder, Generalized Linear Models ,(1983)
Gabriel A. Kune, Susan Kune, Lyndsey F. Watson, Colorectal cancer risk, chronic illnesses, operations, and medications: case control results from the Melbourne Colorectal Cancer Study Cancer Research. ,vol. 48, pp. 4399- 4404 ,(1988)
Denis Labayle, Daniel Fischer, Philippe Vielh, Francois Drouhin, Alex Pariente, Christian Bories, Olivier Duhamel, Michel Trousset, Pierre Attali, Sulindac causes regression of rectal polyps in familial adenomatous polyposis Gastroenterology. ,vol. 101, pp. 635- 639 ,(1991) , 10.1016/0016-5085(91)90519-Q
Monica M. Bertagnolli, Gary J. Kelloff, David S. Alberts, Peter T. Scardino, Wael A. Sakr, Lee W. Wattenberg, Anil K. Rustgi, Adi F. Gazdar, Michele Follen, Joyce A. O’Shaughnessy, Vassiliki A Papadimitrakopoulou, Caroline C. Sigman, Steven P. Stratton, William G. Nelson, Stephen Lam, Carol J. Fabian, Frank L. Meyskens, Michael B. Sporn, Andrew J. Dannenberg, Scott M. Lippman, Gary B. Gordon, Waun Ki Hong, Daniel D. Von Hoff, Treatment and Prevention of Intraepithelial Neoplasia: An Important Target for Accelerated New Agent Development: Recommendations of the American Association for Cancer Research Task Force on the Treatment and Prevention of Intraepithelial Neoplasia Clinical Cancer Research. ,vol. 8, pp. 314- 346 ,(2002)
Til Sturmer, Robert J Glynn, I-Min Lee, JoAnn E Manson, Julie E Buring, Charles H Hennekens, Aspirin Use and Colorectal Cancer: Post-Trial Follow-up Data from the Physicians' Health Study Annals of Internal Medicine. ,vol. 128, pp. 713- 720 ,(1998) , 10.7326/0003-4819-128-9-199805010-00003
R. MacLennan, F. Macrae, C. Bain, D. Battistutta, P. Chapuis, H. Gratten, J. Lambert, R. C. Newland, M. Ngu, A. Russell, M. Ward, M. L. Wahlqvist, , Randomized Trial of Intake of Fat, Fiber, and Beta Carotene to Prevent Colorectal Adenomas Journal of the National Cancer Institute. ,vol. 87, pp. 1760- 1766 ,(1995) , 10.1093/JNCI/87.23.1760