Multicenter Study Using Desorption-Electrospray-Ionization-Mass-Spectrometry Imaging for Breast-Cancer Diagnosis
作者： Andreia M. Porcari , Jialing Zhang , Kyana Y. Garza , Raquel M. Rodrigues-Peres , John Q. Lin
DOI: 10.1021/ACS.ANALCHEM.8B01961
关键词:
摘要: The histological and molecular subtypes of breast cancer demand distinct therapeutic approaches. Invasive ductal carcinoma (IDC) is subtyped according to estrogen-receptor (ER), progesterone-receptor (PR), HER2 status, among other markers. Desorption-electrospray-ionization-mass-spectrometry imaging (DESI-MSI) an ambient-ionization MS technique that has been previously used diagnose IDC. Aiming investigate the robustness for IDC diagnosis subtyping over diverse patient populations interlaboratory use, we report a multicenter study using DESI-MSI analyze samples from 103 patients independently analyzed in United States Brazil. lipid profiles normal tissues were consistent across different races unrelated country sample collection. Similar experimental parameters both laboratories yielded mass-spectral data mass-to-charge ratios (m/z) above 700, where complex lipids are observed. Stati...
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