Differential expression of microRNAs in bovine papillomavirus type 1 transformed equine cells

作者: N. Terron-Canedo , W. Weir , L. Nicolson , C. Britton , L. Nasir

DOI: 10.1111/VCO.12216

关键词:

摘要: Bovine papillomavirus (BPV) types 1 and 2 play an important role in the pathogenesis of equine sarcoids (ES), most common cutaneous tumour affecting horses. MicroRNAs (miRNAs), small non-coding RNAs that regulate essential biological cellular processes, have been found dysregulated a wide range tumours. The aim this study was to identify miRNAs associated with ES. Differential expression assessed control fibroblasts (EqPalFs) EqPalFs transformed BPV-1 genome (S6-2 cells). Using commercially available miRNA microarray, 492 mature were interrogated. In total, 206 differentially expressed compared S6-2 cells. Aberrant these cells can be attributed presence genomes. Furthermore, we confirm 124 previously computationally predicted horse. Our data supports involvement

参考文章(78)
Sam Griffiths-Jones, Russell J Grocock, Stijn Van Dongen, Alex Bateman, Anton J Enright, miRBase: microRNA sequences, targets and gene nomenclature Nucleic Acids Research. ,vol. 34, pp. 140- 144 ,(2006) , 10.1093/NAR/GKJ112
Chen Lin, Fei Huang, Ya-Jing Zhang, Talafu Tuokan, Gulinaer Kuerban, Roles of MiR-101 and its target gene Cox-2 in early diagnosis of cervical cancer in Uygur women. Asian Pacific Journal of Cancer Prevention. ,vol. 15, pp. 45- 48 ,(2014) , 10.7314/APJCP.2014.15.1.45
Juliano C. da Silveira, D.N. Rao Veeramachaneni, Quinton A. Winger, Elaine M. Carnevale, Gerrit J. Bouma, Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle Biology of Reproduction. ,vol. 86, pp. 71- ,(2012) , 10.1095/BIOLREPROD.111.093252
Holger Zimmermann, Choon-Heng Koh, Roland Degenkolbe, Mark J. O’Connor, Andreas Müller, Gertrud Steger, Jason J. Chen, Yun Lui, Elliot Androphy, Hans-Ulrich Bernard, Interaction with CBP/p300 enables the bovine papillomavirus type 1 E6 oncoprotein to downregulate CBP/p300-mediated transactivation by p53. Journal of General Virology. ,vol. 81, pp. 2617- 2623 ,(2000) , 10.1099/0022-1317-81-11-2617
Elizabeth A. Carr, Alain P. Theon, Bruce R. Madewell, Margaret E. Hitchcock, Richard Schlegel, John T. Schiller, Expression of a transforming gene (E5) of bovine papillomavirus in sarcoids obtained from horses. American Journal of Veterinary Research. ,vol. 62, pp. 1212- 1217 ,(2001) , 10.2460/AJVR.2001.62.1212
Amy S Gardiner, William C McBee, Robert P Edwards, Marshall Austin, Jamie L Lesnock, Rohit Bhargava, Richard Guido, Saleem A Khan, MicroRNA analysis in human papillomavirus (HPV)-associated cervical neoplasia and cancer Infectious Agents and Cancer. ,vol. 5, pp. 1- 1 ,(2010) , 10.1186/1750-9378-5-S1-A55
Chao-Hung Hung, Tsung-Hui Hu, Sheng-Nan Lu, Fang-Ying Kuo, Chien-Hung Chen, Jing-Houng Wang, Chao-Min Huang, Chuan-Mo Lee, Chih-Yun Lin, Yi-Hao Yen, Yi-Chun Chiu, Circulating microRNAs as biomarkers for diagnosis of early hepatocellular carcinoma associated with hepatitis B virus International Journal of Cancer. ,vol. 138, pp. 714- 720 ,(2016) , 10.1002/IJC.29802
Xiaohong Wang, Hsu-Kun Wang, J Philip McCoy, Nilam S Banerjee, Janet S Rader, Thomas R Broker, Craig Meyers, Louise T Chow, Zhi-Ming Zheng, Oncogenic HPV infection interrupts the expression of tumor-suppressive miR-34a through viral oncoprotein E6 RNA. ,vol. 15, pp. 637- 647 ,(2009) , 10.1261/RNA.1442309
Paula A. Schaffer, Bruce Wobeser, Laura E. R. Martin, Michelle M. Dennis, Colleen G. Duncan, Cutaneous neoplastic lesions of equids in the central United States and Canada: 3,351 biopsy specimens from 3,272 equids (2000–2010) Javma-journal of The American Veterinary Medical Association. ,vol. 242, pp. 99- 104 ,(2013) , 10.2460/JAVMA.242.1.99
L. Bogaert, M. Van Poucke, C. De Baere, J. Dewulf, L. Peelman, R. Ducatelle, F. Gasthuys, A. Martens, Bovine papillomavirus load and mRNA expression, cell proliferation and p53 expression in four clinical types of equine sarcoid Journal of General Virology. ,vol. 88, pp. 2155- 2161 ,(2007) , 10.1099/VIR.0.82876-0