作者: N. Terron-Canedo , W. Weir , L. Nicolson , C. Britton , L. Nasir
DOI: 10.1111/VCO.12216
关键词:
摘要: Bovine papillomavirus (BPV) types 1 and 2 play an important role in the pathogenesis of equine sarcoids (ES), most common cutaneous tumour affecting horses. MicroRNAs (miRNAs), small non-coding RNAs that regulate essential biological cellular processes, have been found dysregulated a wide range tumours. The aim this study was to identify miRNAs associated with ES. Differential expression assessed control fibroblasts (EqPalFs) EqPalFs transformed BPV-1 genome (S6-2 cells). Using commercially available miRNA microarray, 492 mature were interrogated. In total, 206 differentially expressed compared S6-2 cells. Aberrant these cells can be attributed presence genomes. Furthermore, we confirm 124 previously computationally predicted horse. Our data supports involvement