On-site screening and GC–MS analysis of cocaine and heroin metabolites in body-packers urine

作者: C. Calabrò , M. Pellegrini , R. Pacifici , P. Zuccaro , S. Pichini

DOI: 10.1016/J.JPBA.2007.11.025

关键词:

摘要: Abstract The illicit transportation of cocaine and heroin either swallowed or inserted into the rectum and/or vagina individuals, defined as “body-packers”, is becoming increasingly common. Assessment smuggling by urinalysis from body-packers has been sparsely reported on-site rapid screening methods are essentially lacking. We screened presence metabolites in urine suspected an immunochromatographic test confirmed obtained results gas chromatography–mass spectrometry X-ray examination. Samples were collected 64 individuals (45 men, 19 women) stopped at Fiumicino Ciampino airports Rome (Italy) for suspicion internal concealment between October 2006 July 2007. Urine was immediately Cozart® test. Irrespective results, underwent examination samples analyzed (GC–MS). In 48 out cases (24 positives 24 negatives) GC–MS assay 5 cases, positive to analysis, abdominal radiography negative resulted be drug users. 11 radiological investigation, analysis found benzoylecgonine 10 morphine one case. Concentration both substances all lower than 50 ng/ml compatible with personal use. From detection appears a reliable disclose internally concealed drugs justify subsequent investigations.

参考文章(15)
James R. Gill, Stuart M. Graham, Ten years of "body packers" in New York City: 50 deaths. Journal of Forensic Sciences. ,vol. 47, pp. 843- 846 ,(2002) , 10.1520/JFS15469J
Maciej J. Bogusz, Helmut Althoff, Manfred Erkens, Rolf-Dieter Maier, Rainer Hofmann, Internally Concealed Cocaine: Analytical and Diagnostic Aspects Journal of Forensic Sciences. ,vol. 40, pp. 811- 815 ,(1995) , 10.1520/JFS15390J
Mitona Pujadas, Simona Pichini, Ester Civit, Elena Santamariña, Katherine Perez, Rafael de la Torre, A simple and reliable procedure for the determination of psychoactive drugs in oral fluid by gas chromatography-mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis. ,vol. 44, pp. 594- 601 ,(2007) , 10.1016/J.JPBA.2007.02.022
Manuela Pellegrini, Adriana Casá, Emilia Marchei, Roberta Pacifici, Ruth Mayné, Vanessa Barbero, Oscar Garcia-Algar, Simona Pichini, Development and validation of a gas chromatography-mass spectrometry assay for opiates and cocaine in human teeth. Journal of Pharmaceutical and Biomedical Analysis. ,vol. 40, pp. 662- 668 ,(2006) , 10.1016/J.JPBA.2005.07.003
Steven A. Koehler, Shaun Ladham, Leon Rozin, Abdulrezak Shakir, Bennet Omalu, Joseph Dominick, Cyril H. Wecht, The risk of body packing: a case of a fatal cocaine overdose. Forensic Science International. ,vol. 151, pp. 81- 84 ,(2005) , 10.1016/J.FORSCIINT.2004.07.005
Vittorio Fineschi, Fabio Centini, Floriana Monciotti, Emanuela Turillazzi, The cocaine "body stuffer" syndrome: a fatal case. Forensic Science International. ,vol. 126, pp. 7- 10 ,(2002) , 10.1016/S0379-0738(02)00011-7
Dwight R. Cordero, Carlos Medina, Andrew Helfgott, Cocaine body packing in pregnancy Annals of Emergency Medicine. ,vol. 48, pp. 323- 325 ,(2006) , 10.1016/J.ANNEMERGMED.2006.02.019
Romain Gherardi, Bernard Marc, Xavier Alberti, Fréderic Baud, Odile Diamant-Berger, A cocaine body packer with normal abdominal plain radiograms. Value of drug detection in urine and contrast study of the bowel. American Journal of Forensic Medicine and Pathology. ,vol. 11, pp. 154- 157 ,(1990) , 10.1097/00000433-199006000-00010
A Chakrabarty, Smuggling contraband drugs using paediatric "body packers". Archives of Disease in Childhood. ,vol. 91, pp. 51- 51 ,(2005) , 10.1136/ADC.2005.080507
RomainK. Gherardi, Pierre Leporc, Jean-Pierre Dupeyron, FredericJ. Baud, Bernard Marc, Odile Diamant-Berger, Detection of drugs in the urine of body-packers. The Lancet. ,vol. 331, pp. 1076- 1078 ,(1988) , 10.1016/S0140-6736(88)91897-1