Lrp6-mediated canonical Wnt signaling is required for lip formation and fusion
作者： L. Song , Y. Li , K. Wang , Y.-Z. Wang , A. Molotkov
DOI: 10.1242/DEV.037440
关键词:
摘要: Neither the mechanisms that govern lip morphogenesis nor cause of cleft are well understood. We report genetic inactivation Lrp6, a co-receptor Wnt/β-catenin signaling pathway, leads to with palate. The activity Wnt reporter is blocked in orofacial primordia by Lrp6 deletion mice. morphological dynamic required for normal formation and fusion disrupted these mutants. expression homeobox genes Msx1 Msx2 dramatically reduced mutants, which prevents outgrowth primordia, especially site. further demonstrate (but not their potential regulator Bmp4 ) downstream targets pathway during fusion. By contrast, `fusion-resistant' gene, Raldh3 (also known as Aldh1a3 ), encodes retinoic acid-synthesizing enzyme ectopically expressed upper Lrp6-deficient embryos, indicating region-specific role repressing acid signaling. Thus, Lrp6-mediated development orchestrating two distinctively different morphogenetic movements.
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Jennifer Willert, Mirjam Epping, Jonathan R Pollack, Patrick O Brown, Roel Nusse, A transcriptional response to Wnt protein in human embryonic carcinoma cells. BMC Developmental Biology. ,vol. 2, pp. 8- 8 ,(2002) , 10.1186/1471-213X-2-8
Ichiro Satokata, Liang Ma, Hayato Ohshima, Marianna Bei, Ian Woo, Kazumichi Nishizawa, Takeyasu Maeda, Yoshiro Takano, Makoto Uchiyama, Shaun Heaney, Heiko Peters, Zequn Tang, Robert Maxson, Richard Maas, Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation. Nature Genetics. ,vol. 24, pp. 391- 395 ,(2000) , 10.1038/74231
Martín I. García-Castro, Christophe Marcelle, Marianne Bronner-Fraser, Ectodermal Wnt function as a neural crest inducer. Science. ,vol. 297, pp. 848- 851 ,(2002) , 10.1126/SCIENCE.1070824
Kathleen I. Pinson, Jane Brennan, Susan Monkley, Brian J. Avery, William C. Skarnes, An LDL-receptor-related protein mediates Wnt signalling in mice. Nature. ,vol. 407, pp. 535- 538 ,(2000) , 10.1038/35035124
Ichiro Satokata, Richard Maas, Msx1 deficient mice exhibit cleft palate and abnormalities of craniofacial and tooth development Nature Genetics. ,vol. 6, pp. 348- 356 ,(1994) , 10.1038/NG0494-348
S.-H. Lee, K. K. Fu, J. N. Hui, J. M. Richman, Noggin and retinoic acid transform the identity of avian facial prominences Nature. ,vol. 414, pp. 909- 912 ,(2001) , 10.1038/414909A
Yoshiaki Kassai, Pauliina Munne, Yuhei Hotta, Enni Penttilä, Kathryn Kavanagh, Norihiko Ohbayashi, Shinji Takada, Irma Thesleff, Jukka Jernvall, Nobuyuki Itoh, Regulation of mammalian tooth cusp patterning by ectodin. Science. ,vol. 309, pp. 2067- 2070 ,(2005) , 10.1126/SCIENCE.1116848
Jinseol Rhee, Tim Buchan, Lawrence Zukerberg, Jack Lilien, Janne Balsamo, Cables links Robo-bound Abl kinase to N-cadherin-bound β-catenin to mediate Slit-induced modulation of adhesion and transcription Nature Cell Biology. ,vol. 9, pp. 883- 892 ,(2007) , 10.1038/NCB1614
Jun Li, Fabian Chen, Jonathan A. Epstein, Neural crest expression of Cre recombinase directed by the proximal Pax3 promoter in transgenic mice. Genesis. ,vol. 26, pp. 162- 164 ,(2000) , 10.1002/(SICI)1526-968X(200002)26:2<162::AID-GENE21>3.0.CO;2-R
Yoshihiro Ito, Jae Yong Yeo, Anna Chytil, Jun Han, Pablo Bringas Jr, Akira Nakajima, Charles F Shuler, Harold L Moses, Yang Chai, Conditional inactivation of Tgfbr2 in cranial neural crest causes cleft palate and calvaria defects. Development. ,vol. 130, pp. 5269- 5280 ,(2003) , 10.1242/DEV.00708