Association between Helicobacter bilis in bile and biliary tract malignancies: H. bilis in bile from Japanese and Thai patients with benign and malignant diseases in the biliary tract.
作者： Norio Matsukura , Shigeki Yokomuro , Sirikan Yamada , Takashi Tajiri , Trichak Sundo
DOI: 10.1111/J.1349-7006.2002.TB01327.X
关键词:
摘要: Japan and Thailand have high incidences of bile duct carcinoma gallstones. The presence Helicobacter bilis (H. bilis) detected by polymerase chain reaction (PCR) 16S rRNA analysis in samples from Chileans with chronic cholecystitis was reported. association between H. biliary tract malignancies has not been investigated, therefore the aim this study is to determine whether malignant diseases are associated obtained two high-risk populations. Bile 45 Japanese 40 Thai patients were subjected PCR using bilis-specific primers, six amplicons sequenced. Thirteen out 15 (87%) 11 14 (79%) or gallbladder cancer tested positive for their bile. Eight 16 (50%) 10 26 (38%) gallstone / bilis. Only 4 (29%) subjects without disease among Japanese. showed significantly higher rates than did non-biliary (P < 0.01) odds ratios comparison 6.50 (95%CI 1.09 - 38.63) 5.86 (1.31 26.33) patients. In conclusion, infection cancers risk populations, Thai.
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