Helicobacter hepaticus and Helicobacter bilis: proinflammatory modulators of enterohepatic disease

摘要: Using Steiner’s silver stain a bacterium with spiral to curved morphology was observed in livers of control A/JCr mice hepatitis, hepatic adenomas and hepatocellular carcinomas1. A Gram-negative bipolar, single-sheathed flagella, isolated from these diseased livers, maintained on long-term carcinogenicity study, characterized named H. hepaticus 2. Since its original observation 1991, is now known be prevalent many mouse colonies, commercial academic, throughout the world3. In addition mice, causes hepatitis BALB/cCr, SJL/NCr, SCID/NCr, C3H/ HeNCr AxB recombinant strains. Like AJ/CR infection B6C3F1 associated liver cancer. Because hepaticus’ ecological niche lower bowel, organism can also readily faeces, faecal-oral transmission suspected. For example, either caecum or colon 100% surveyed during longitudinal study4. Thus, for routine diagnosis infected isolation should attempted distal part intestine, not parenchyma. The persistent nature infection, usually without overt clinical signs wild-type may contribute high prevalence academic colonies3,5. Recently, because negative impact Helicobacter infections biomedical research, considerable effort has been expended derive Helicobacter-free colonies at several vendors United States.