Vaccination against parasitic diseases: some alternative concepts for the definition of protective antigens.
作者： A. Capron , J.P. Dessaint
DOI: 10.1016/0769-2625(88)90135-3
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摘要: Abstract La definition d'une strategie vaccinale vis-a-vis des maladies parasitaires a longtemps repose sur le concept d'antigene specifiques de stades evolutifs, exposes la surface du parasite. D'un point vue evolutif, il semble preferable d'envisager que les structures fonctionnelles essentielles pour parasite n'obeissent pas ces criteres mais correspondent plutot exprimees maniere transitoire et avec d'autres topographies autres stades. Enfin, demonstration qu'un meme antigene peut entrainer production d'anticorps protecteurs bloquants, amene reconsiderer l'importance l'isotype anticorps produit lors immunisation. A l'aide nouveaux concepts, une pu etre developpee schistosomiases, son application modeles d'infection chronique est discutee.
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