Acylated chitosan anchored paclitaxel loaded liposomes: Pharmacokinetic and biodistribution study in Ehrlich ascites tumor bearing mice.

摘要: Abstract Acylated chitosan (Myristoyl and Octanoyl) coated paclitaxel-loaded liposomal formulation was developed with an aim to overcome the cremophor EL related toxicities. They were evaluated for drug entrapment, in vitro release, cytotoxicity cell uptake behavior using A549 cells. The 99mTc radio-labeled formulations also vivo Ehrlich Ascites Tumor (EAT) bearing mice biodistribution tumor uptake. mean particle size of both uncoated found be range 180–200 nm high entrapment efficiency (>90% case liposomes 80 ± 5% liposomes). displayed negative zeta potential (−10.5 ± 4.9 mV) whereas positive +21 +27 mV. Slower release observed acylated chitosans as compared native liposomes. All less cytotoxic than paclitaxel injection (Celtax™, Celon Labs, India). In intracellular distribution studies confirmed cytosolic delivery myristoyl system (LMC) exhibited improved pharmacokinetic, characteristics over other formulations. These obtained results application chitosn systems targeting drugs.