Technetium-labeled danofloxacin complex as a model for infection imaging

摘要: Abstract Danofloxacin, a fluoroquinolone derivative antibiotic, was synthesized, successfully labeled with technetium-99m and formulated for the development of potential diagnostic imaging agent bacterial infection inflammation higher efficiency than that commercially available 99mTc-ciprofloxacin. Factors affecting labeling yield were optimized. The radiolabeled antibiotic subjected to preclinical assessments such as purity, stability, pharmacokinetic investigations in animals. biodistribution studies indicated uptake 99mTc-danofloxacin high infectious lesion (T/NT = 7.2 ± 0.1) at 2 h post injection. abscess normal ratio danofloxacin tracer can be used diagnosis. compound cleared quickly from most body organs. results displayed could not differentiate between sterile inflammation.