Expression of a Novel N-Acetylglucosaminyltransferase in Rat Hepatic Nodules

摘要: The hallmark of liver cancer research in recent years has been the development experimental models by which initiation, promotion and progression phases can be studied1–4. Even though several agents act as promoters, yet many them are organ specific. Nonetheless, orotic acid is elegant that selecting initiating carcinogen both liver5,6 well intestine7 achieved. Being an intermediate de novo biosynthesis pyrimidine nucleotides, rapidly metabolized to uridine on accumulation creates imbalance pool sizes nucleotides. Interestingly, reversed either blocking conversion into nucleotides or trapping accumulated nucleotides8. These observations suggest may have important role phase carcinogenic process. An understanding metabolic principles underlying induced tumor therefore requires a study effect macromolecular biogenesis involving template process such nucleic synthesis non-template like glycosylation. Glycosylation being regulated number factors including level availability nucleotide sugars.