The Role of TAL1 in Hematopoiesis and Leukemogenesis.
作者： E. R. Vagapova , P. V. Spirin , T. D. Lebedev , V. S. Prassolov
DOI: 10.32607/20758251-2018-10-1-15-23
关键词:
摘要: TAL1 (SCL/TAL1, T-cell acute leukemia protein 1) is a transcription factor that involved in the process of hematopoiesis and leukemogenesis. It participates blood cell formation, forms mesoderm early embryogenesis, regulates adult organisms. essential maintaining multipotency hematopoietic stem cells (HSC) keeping them quiescence (stage G0). complexes with various factors, regulating (E2A/HEB, GATA1-3, LMO1-2, Ldb1, ETO2, RUNX1, ERG, FLI1). In these complexes, normal myeloid differentiation, controls proliferation erythroid progenitors, determines choice direction HSC differentiation. The factors TAL1, E2A, GATA1 (or GATA2), LMO2, Ldb1 are major components SCL complex. addition to hematopoiesis, this complex may also be malignant transformation. Upregulation C-KIT expression one main roles played by Today, its partners considered promising therapeutic targets treatment lymphoblastic leukemia.
sci-hub.st 参考文章(68)
AR Kallianpur, JE Jordan, SJ Brandt, The SCL/TAL-1 gene is expressed in progenitors of both the hematopoietic and vascular systems during embryogenesis Blood. ,vol. 83, pp. 1200- 1208 ,(1994) , 10.1182/BLOOD.V83.5.1200.1200
Q. Chen, J.T. Cheng, L.H. Tasi, N. Schneider, G. Buchanan, A. Carroll, W. Crist, B. Ozanne, M.J. Siciliano, R. Baer, The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein. The EMBO Journal. ,vol. 9, pp. 415- 424 ,(1990) , 10.1002/J.1460-2075.1990.TB08126.X
Carmen G Palii, Carolina Perez-Iratxeta, Zizhen Yao, Yi Cao, Fengtao Dai, Jerry Davison, Harold Atkins, David Allan, F Jeffrey Dilworth, Robert Gentleman, Stephen J Tapscott, Marjorie Brand, Differential genomic targeting of the transcription factor TAL1 in alternate haematopoietic lineages The EMBO Journal. ,vol. 30, pp. 494- 509 ,(2011) , 10.1038/EMBOJ.2010.342
J T Cheng, M H Cobb, R Baer, Phosphorylation of the TAL1 oncoprotein by the extracellular-signal-regulated protein kinase ERK1. Molecular and Cellular Biology. ,vol. 13, pp. 801- 808 ,(1993) , 10.1128/MCB.13.2.801
Aissa Benyoucef, Julien Calvo, Laurent Renou, Marie-Laure Arcangeli, Anita van den Heuvel, Sophie Amsellem, Maryam Mehrpour, Jerome Larghero, Eric Soler, Irina Naguibneva, Francoise Pflumio, The SCL/TAL1 Transcription Factor Represses the Stress Protein DDiT4/REDD1 in Human Hematopoietic Stem/Progenitor Cells Stem Cells. ,vol. 33, pp. 2268- 2279 ,(2015) , 10.1002/STEM.2028
C. Glenn Begley, Anthony R. Green, The SCL gene: from case report to critical hematopoietic regulator. Blood. ,vol. 93, pp. 2760- 2770 ,(1999) , 10.1182/BLOOD.V93.9.2760
Marija Vlaški, Slavko Mojsilović, Nevenka Stojanović, Diana Bugarski, Aleksandra Krstić, Gordana Jovčić, Marijana Petakov, Pavle Milenković, Signaling pathways implicated in hematopoietic progenitor cell proliferation and differentiation. Experimental Biology and Medicine. ,vol. 232, pp. 156- 163 ,(2007) , 10.3181/00379727-207-2320156
Miguel G Toscano, Oscar Navarro-Montero, Veronica Ayllon, Veronica Ramos-Mejia, Xiomara Guerrero-Carreno, Clara Bueno, Tamara Romero, Mar Lamolda, Marien Cobo, Francisco Martin, Pablo Menendez, Pedro J Real, None, SCL/TAL1-mediated Transcriptional Network Enhances Megakaryocytic Specification of Human Embryonic Stem Cells Molecular Therapy. ,vol. 23, pp. 158- 170 ,(2015) , 10.1038/MT.2014.196
Muge Sayitoglu, Yucel Erbilgin, Ozden Hatirnaz, Inci Yildiz, Tiraje Celkan, Sema Anak, Omer Devecioglu, Gonul Aydogan, Serap Karaman, Nazan Sarper, Cetin Timur, Umit Ure, Ugur Ozbek, Upregulation of T-Cell-Specific Transcription Factor Expression in Pediatric T-Cell Acute Lymphoblastic Leukemia (T-ALL). Turkish Journal of Hematology. ,vol. 29, pp. 325- 333 ,(2012) , 10.5505/TJH.2012.13540
Nicolas Goardon, Julie A Lambert, Patrick Rodriguez, Philippe Nissaire, Sabine Herblot, Pierre Thibault, Dominique Dumenil, John Strouboulis, Paul-Henri Romeo, Trang Hoang, ETO2 coordinates cellular proliferation and differentiation during erythropoiesis The EMBO Journal. ,vol. 25, pp. 357- 366 ,(2006) , 10.1038/SJ.EMBOJ.7600934