Hardware-in-the-loop control of glucose in diabetic patients based on nonlinear time-varying blood glucose model

作者: Farnoosh Rahmanian , Maryam Dehghani , Paknoosh Karimaghaee , Mohsen Mohammadi , Roozbeh Abolpour

DOI: 10.1016/J.BSPC.2021.102467

关键词:

摘要: Abstract Diabetes Mellitus (DM) is identified as one of the most serious public health challenges which need engineering science to deal with and prevent complications. In this paper, a model glucose-insulin system for virtual type 1 diabetic patient controlled, considers factors such physical mental characteristics patient. The purpose paper consider nonlinear time-varying patients affected by Exercise, stress, fatigue, meals, snacks, sensitivity insulin (SI) design an appropriate controller based on backstepping (BS) technique. order make robust uncertainties in reality, level food, snack, exercise are considered unknown continuous functions designed that it can cope these while blood glucose regulated. To verify performance controllers, sample pump manufactured Hardware-In-The-Loop (HIL) experiment carried out. result HIL test compared in-silico simulation shows success regulating preventing from complications hyperglycemia hypoglycemia.

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