Salivary proteins promote proteolytic activity in Streptococcus mitis biovar 2 and Streptococcus mutans

摘要: Summary A major function of the salivary pellicle on oral surfaces is to promote colonization commensal microbiota by providing binding sites for adherence. Streptococcus mitis an early colonizer cavity whereas mutans represents a later colonizer. To survive and grow, bacteria produce enzymes, proteases glycosidases, which allow them exploit proteins as nutrient source. In this study, adherence proteolytic activity S. mitis biovar 2 S. mutans were investigated in flow-cell model presence different populations surface-associated proteins. adhered well coated with both MUC5B-enriched fraction pool low-density containing MUC7, amylase, cystatin, gp340, immunoglobulin A, lactoferrin, lysozyme statherin, these was poor. environments MUC5B or proteins, showed high levels activity. For environment, most may be attributable contact molecules fluid phase although also enhanced MUC5B. These data suggest that they differ their capacity adhere natural environment exploitation saliva source can contribute survival S. mutans.