Reinvestigating hyperpolarized (129)Xe longitudinal relaxation time in the rat brain with noise considerations.
作者： X. Zhou , M. L. Mazzanti , J. J. Chen , Y.-S. Tzeng , J. K. Mansour
DOI: 10.1002/NBM.1184
关键词:
摘要: The longitudinal relaxation time of hyperpolarized (HP) (129)Xe in the brain is a critical parameter for developing HP imaging and spectroscopy optimizing pulse sequences, especially case cerebral blood flow measurements. Various studies have produced widely varying estimates T(1) rat brain. To make improved measurements investigate how low signal-to-noise ratio (SNR) contributes to these discrepancies, we developed multi-pulse protocol during washout from Afterwards, applied an SNR threshold theory both existing two-pulse protocol. two protocols yielded mean +/- SD values 15.3 1.2 16.2 0.9 s, suggesting that might be key reason wide range published literature, problem easily alleviated by taking levels into account.
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