Distribution of Hyperpolarized Xenon in the Brain Following Sensory Stimulation: Preliminary MRI Findings

摘要: In hyperpolarized xenon magnetic resonance imaging (HP 129Xe MRI), the inhaled spin-1/2 isotope of gas is used to generate MR signal. Because an signal source with properties very different from those generated water-protons, HP MRI may yield structural and functional information not detectable by conventional proton-based methods. Here we demonstrate differential distribution in cerebral cortex rat following a pain stimulus evoked animal's forepaw. Areas higher corresponded areas previously demonstrated (fMRI) methods as being activated forepaw stimulus. The percent increase over baseline was 13–28%, single set pre post images. Recent innovations production highly polarized should make feasible emergence viable adjunct method for study brain function disease.