High sugar intake exacerbates cardiac reperfusion injury in perinatal taurine depleted adult rats

摘要: Perinatal taurine depletion and high sugar diets blunted baroreflex function heightens sympathetic nerve activity in adult rats. Cardiac ischemia/reperfusion also produces these disorders treatment appears to improve effects. This study tests the hypothesis that perinatal exposure predisposes recovery from reperfusion injury rats on either a basal or diet. Female Sprague-Dawley were fed normal rat chow with 3% beta-alanine (taurine depletion, TD), supplementation, TS) water alone (control, C) conception weaning. Male offspring containing 5% glucose (G) (W) throughout experiment. At 7-8 weeks of age, all anesthetized their trachea clamped until cardiac arrest occurred mean arterial pressure fell below 60 mm Hg. The clamp was immediately released cardiopulmonary resuscitation performed returning within 4 min. Twenty-four hours later, pressure, heart rate, measured conscious one day later conditions. Basic blood chemistry circulating markers measured. Baroreflex sensitivity depressed moderately CG TDW, severely TDG. TSW displayed increased intake returned it CW. Sympathetic parasympathetic decreased TDW but not effects exacerbated sharply TDG slightly TSG. Arterial rate groups lesser degree Plasma aspartate aminotransferase except TSW, increase nearly 3X greater vs. any other group. Creatine kinase-MB TSG far TD than groups. Troponin-T brain natriuretic peptide greatly compared Thus, increases ischemia/reperfusion, diet, are exacerbated.