Taurine-mediated cardioprotection is greater when administered upon reperfusion than prior to ischemia.
作者： Tadaomi-Alfonso Miyamoto , Takayuki Ueno , Yoshihumi Iguro , Goichi Yotsumoto , Yoshihiro Fukumoto
DOI: 10.1007/978-0-387-75681-3_3
关键词:
摘要: Taurine (TA) administered exogenously before the induction of myocardial ischemia decreases lactic acid production and increases pyruvic during ischemia. It also preserves activity GOT, GPT, LDH CPK enhances recovery CKMB synthesis as early 5 minutes after onset reperfusion. The aim study was to determine optimal conditions for administering TA in order reduce ischemia-reperfusion injury. Left ventricular (LV) function, creatine kinase (CK) lipid peroxide products (LPOP=oxidant stress), well area at risk (AAR), infarct size (IS) reperfusion were studied 3 groups isolated rat hearts perfused with Krebs Henseleit Buffer (KHB)-stabilized that subjected 20 minutes(’) global 37o followed by 60′ KHB: Hearts containing KHB 10′ just prior or first 10’ Conclusion:Taurine equally effective preventing infarction; however, when reperfusion, taurine reduced peroxidation injury more, thereby providing improved function.
springer.com
sci-hub.st 参考文章(43)
Wnimunk Oriyanhan, Tadaomi A. Miyamoto, Kazuhiro Yamazaki, Senri Miwa, Kiyoaki Takaba, Tadashi Ikeda, Masashi Komeda, Minimizes Lactic Acidosis and Preserves CKMB and Myocardial Contractility after Ischemia/Reperfusion Advances in Experimental Medicine and Biology. ,vol. 583, pp. 271- 278 ,(2006) , 10.1007/978-0-387-33504-9_30
Charles E. Ganote, Robert B. Jennings, Daniel A. Whalen, Donald G. Hamilton, Effect of a Transient Period of Ischemia on Myocardial Cells: I. Effects on Cell Volume Regulation American Journal of Pathology. ,vol. 74, pp. 381- 397 ,(1974)
Koho J. Miyamoto, Masumi R. Miyamoto, Tadaomi A. Miyamoto, Part III. Systemically administered taurine : Pharmacologically activated mechanisms Advances in Experimental Medicine and Biology. ,vol. 583, pp. 335- 351 ,(2006) , 10.1007/978-0-387-33504-9_38
Wnimunk Oriyanhan, Tadaomi A. Miyamoto, Kazuhiro Yamazaki, Senri Miwa, Kiyoaki Takaba, Tadashi Ikeda, Masashi Komeda, Taurine Addition to St Thomas’ Solution Prevents DNA Oxidative Stress and Maintains Contractile Function Advances in Experimental Medicine and Biology. ,vol. 583, pp. 279- 288 ,(2006) , 10.1007/978-0-387-33504-9_31
Camilla Köhler, Annie Gahm, Takafumi Noma, Atsushi Nakazawa, Sten Orrenius, Boris Zhivotovsky, Release of adenylate kinase 2 from the mitochondrial intermembrane space during apoptosis FEBS Letters. ,vol. 447, pp. 10- 12 ,(1999) , 10.1016/S0014-5793(99)00251-3
John J. Lemasters, Anna-Liisa Nieminen, Ting Qian, Lawrence C. Trost, Brian Herman, The mitochondrial permeability transition in toxic, hypoxic and reperfusion injury Molecular and Cellular Biochemistry. ,vol. 174, pp. 159- 165 ,(1997) , 10.1023/A:1006827601337
Svend Høime Hansen, Mogens Larsen Andersen, Henrik Birkedal, Claus Cornett, Flemming Wibrand, The important role of taurine in oxidative metabolism. Advances in Experimental Medicine and Biology. ,vol. 583, pp. 129- 135 ,(2006) , 10.1007/978-0-387-33504-9_13
Gisela Beutner, Alexander Rück, Birgit Riede, Dieter Brdiczka, Complexes between porin, hexokinase, mitochondrial creatine kinase and adenylate translocator display properties of the permeability transition pore. Implication for regulation of permeability transition by the kinases. Biochimica et Biophysica Acta. ,vol. 1368, pp. 7- 18 ,(1998) , 10.1016/S0005-2736(97)00175-2
P. A. Grace, Ischaemia‐reperfusion injury British Journal of Surgery. ,vol. 81, pp. 637- 647 ,(2005) , 10.1002/BJS.1800810504
Eser Öz, Deniz Erbaş, Ethem Gelir, Aysel Aricioğlu, Taurine and calcium interaction in protection of myocardium exposed to ischemic reperfusion injury. General Pharmacology-the Vascular System. ,vol. 33, pp. 137- 141 ,(1999) , 10.1016/S0306-3623(98)00284-5