Long noncoding RNAs as potential biomarkers in retinoblastoma: a systematic review and meta-analysis

摘要: Retinoblastoma is the most common malignant rare intraocular tumor of childhood. Long noncoding RNAs (lncRNAs) have been reported participating in its progression, but their significance remains inconclusive. We conducted this systematic review and meta-analysis to explore specific lncRNA biomarker patients with retinoblastoma. Eligible articles were searched from Pubmed, Web Science, Embase Cochrane library. Hazard ratios (HRs) odds (ORs) extracted or calculated evaluate relationship between lncRNAs The part was STATA v.15 software. A total 9 834 retinoblastoma are yielded. Heterogeneity among HRs overall survival (OS) notably high (I2 = 91.3%, p < 0.001). Subgroup analysis suggests that elevated expression BDNF-AS MT1JP favorable factors OS (pooled HR = 1.89, 95% CI 1.72–2.07, I2 = 0%). Six included optic nerve invasion as a clinicopathological outcome showed notable correlation HR = 2.38, 1.26–3.50, I2 = 0.0%). validate our via public dataset also sum up studies other cancers. Differential has Some them potential prognosis progression.