Cardiorespiratory fitness levels and moderators in people with HIV: A systematic review and meta-analysis.

摘要: Cardiorespiratory fitness (CRF) is a modifiable risk factor for cardiovascular disease and premature mortality. CRF levels moderators among people living with HIV (PLWH) are unknown. The aim of the current meta-analysis was to (1) determine mean in PLWH compare age- gender-matched healthy controls (HCs), (2) explore CRF, (3) (4) outcomes following physical activity (PA) interventions. Major electronic databases were searched systematically articles reporting expressed as maximum or peak oxygen uptake (ml/min/kg) PLWH. A random effects calculating pooled including subgroup- meta-regression analyses undertaken. Across 21 eligible studies, level 26.4ml/kg/min (95% CI=24.6 28.1) (n=1010; age=41years). There insufficient data HCs. higher body mass index (β=-0.99, 95% CI=-1.93 -0.06, P=0.04), older age (β=-0.31, CI=-0.58 -0.04, P=0.02) presence lipodystrophy (β=-4.63, CI=-7.88 -1.39, P=0.005) significant lower levels. Higher CD4+ counts (β=0.004, CI=0.0007 0.007, P=0.016), supervised interventions (P<0.001) frequency weekly sessions (2 3 versus 4 times) predicted better CRF-outcome PA. lowest comparison other vulnerable populations. More research on most optimal intervention characteristics needed.