Demonstration of the genuine iso-12p character of the standard marker chromosome of testicular germ cell tumors and identification of further chromosome 12 aberrations by competitive in situ hybridization.
作者： Chcm Buys , Ay Vandeveen , Jj Cassiman , Da Warburton , D Schonk
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摘要: The recently developed competitive in situ hybridization (CISH) strategy was applied to the analysis of chromosome 12 aberrations testicular germ cell tumors (TGCTs). DNAs from two rodent-human somatic hybrids, containing either a normal or p arm as their unique human material, were used probes. Our results demonstrate genuine iso-12p character standard marker TGCTs. Moreover, variant markers identified representing translocation products that also involve 12.
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