Localization and polymorphism of a chromosome 12-specific alpha satellite DNA sequence.
作者： L.H.J. Looijenga , V.T.H.B.M. Smit , J.W. Wessels , P. Mollevanger , J.W. Oosterhuis
DOI: 10.1159/000132934
关键词: Molecular biology 、 Biology 、 Genetics 、 Chromosome 22 、 Chromosome 12 、 HindIII 、 Restriction fragment length polymorphism 、 Restriction enzyme 、 Marker chromosome 、 Genetic marker 、 Southern blot
摘要: The isolation and localization of a chromosome 12-specific alpha satellite DNA sequence, p 12H8, is described. This clone contains complete copy the 1.4-kb HindIII higher-order repeat present within array on 12. specificity 12H8 was demonstrated by in situ hybridization Southern blot analysis somatic cell hybrid mapping panel, both performed under high-stringency conditions. Polymorphic restriction patterns array, revealed use enzymes BglII EcoRV, were to display Mendelian inheritance. These properties make valuable genetic marker for centromeric region
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