Dynamic contrast-enhanced magnetic resonance imaging is a poor measure of rectal cancer angiogenesis.

摘要: Dynamic contrast-enhanced magnetic resonance imaging is a poor measure of rectal cancer angiogenesis Background: The aim this study was to investigate the use (MRI) for non-invasive measurement and hypoxia. Methods: Fifteen patients with adenocarcinoma underwent preoperative dynamic (DCE) blood oxygenation level-dependent (BOLD) MRI. Microvessel density (CD31 level), expression vascular endothelial growth factor (VEGF) carbonic anhydrase (CA) 9 were measured immunohistochemically in histological turnout sections from 12 patients. Serum VEGF levels also 14 Correlations between quantitative indices immunohistochemical variables examined. Results: There good correlation circulating CD31 (r(s) = 0.88, P < 0.001). did not correlate any MRI parameter, except transfer constant, which it correlated inversely -0.65, 0.022). Tissue correlate, neither DCE parameter. No relationship seen BOLD CA-9 expression. Conclusion: negative constant (reflecting flow microvessel permeability) paradoxical. methods assessing tissue vascularity poorly markers hypoxia, suggesting that does simply reflect static properties cancer.