A Distinct Oncogenerative Multinucleated Cancer Cell Serves as a Source of Stemness and Tumor Heterogeneity.

摘要: The effects of anticancer treatments on cell heterogeneity and their proliferative potential play an important role in tumor persistence metastasis. However, little is known about de-polyploidization, fate, physiologic stemness the resulting populations. Here, we describe a distinctive type termed "pregnant" P1 cells found within chemotherapy-refractory ovarian tumors, which generate gestate daughter generation Gn intracytoplasmically. Release occurred by ejection through crevices membrane body contractions or using funiculus-like structure. These events characterized not yet described mechanism segregation. Maternal were principally capable surviving parturition continued to breed nurture progenies. In addition, competent horizontally transmit offspring into other specific proximal cells, injecting them receptor R1 via cell–cell tunneling. This process represents new used invade surrounding tissues ensure life cycles. contrast pregnant with low expression stem markers despite stemness, first generations G1 expressed high levels cancer markers. Furthermore, both overexpressed multiple human endogenous retroviral envelope proteins. Moreover, programmed death-ligand 1 immunosuppressive domain proteins also suggesting effective protection against host immune system. Together, our data suggest that oncogenerative exhibit biological transmission malignant patients advanced cancers. Significance: entities express CSC markers, are characteristic histological origin. Cancer Res; 78(9); 2318–31. ©2018 AACR.