Delineating the TGF-β/Smad-Induced Cytostatic Response
作者： Fang Liu
关键词:
摘要: TGF-β potently inhibits cell proliferation by causing cycle arrest at the G1 phase. It exerts antiproliferative response through inhibition of CDK activities. Smads play key roles in mediating growth-inhibitory response. downregulate expression protooncogene product c-Myc and inhibitor differentiation Id (Id1, Id2, Id3) upregulate inhibitors p15 p21. The mechanisms for TGF-β/Smad vary considerably from one type to another. intensity cytostatic effect is dependent on a combinatorial nature. crucial guardian tissue homeostasis. Accordingly, are tumor suppressors during early stages tumorigenesis. Understanding program important better preventing treating cancers
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Joanna E. Burdette, Jacqueline S. Jeruss, Sarah J. Kurley, Eun Jig Lee, Teresa K. Woodruff, Activin A Mediates Growth Inhibition and Cell Cycle Arrest through Smads in Human Breast Cancer Cells Cancer Research. ,vol. 65, pp. 7968- 7975 ,(2005) , 10.1158/0008-5472.CAN-04-3553
Anna Lasorella, Michela Noseda, Mercedes Beyna, Antonio Iavarone, Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins Nature. ,vol. 407, pp. 592- 598 ,(2000) , 10.1038/35036504
Shizhen Emily Wang, Frederick Y. Wu, Incheol Shin, Shimian Qu, Carlos L. Arteaga, Transforming Growth Factor β (TGF-β)-Smad Target Gene Protein Tyrosine Phosphatase Receptor Type Kappa Is Required for TGF-β Function Molecular and Cellular Biology. ,vol. 25, pp. 4703- 4715 ,(2005) , 10.1128/MCB.25.11.4703-4715.2005
Michael B. Datto, Joshua P. Frederick, Lihua Pan, Anita J. Borton, Yuan Zhuang, Xiao-Fan Wang, Targeted Disruption of Smad3 Reveals an Essential Role in Transforming Growth Factor β-Mediated Signal Transduction Molecular and Cellular Biology. ,vol. 19, pp. 2495- 2504 ,(1999) , 10.1128/MCB.19.4.2495
Xin-Hua Feng, Xia Lin, Rik Derynck, Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15Ink4B transcription in response to TGF‐β The EMBO Journal. ,vol. 19, pp. 5178- 5193 ,(2000) , 10.1093/EMBOJ/19.19.5178
Sagrario Ortega, Marcos Malumbres, Mariano Barbacid, Cyclin D-dependent kinases, INK4 inhibitors and cancer. Biochimica et Biophysica Acta. ,vol. 1602, pp. 73- 87 ,(2002) , 10.1016/S0304-419X(02)00037-9
Mark E. Ewen, Hayla K. Sluss, Laura L. Whitehouse, David M. Livingston, TGFβ inhibition of Cdk4 synthesis is linked to cell cycle arrest Cell. ,vol. 74, pp. 1009- 1020 ,(1993) , 10.1016/0092-8674(93)90723-4
Yuan Zhu, James A Richardson, Luis F Parada, Jonathan M Graff, Smad3 Mutant Mice Develop Metastatic Colorectal Cancer Cell. ,vol. 94, pp. 703- 714 ,(1998) , 10.1016/S0092-8674(00)81730-4
Anny Kretschmer, Kristin Moepert, Sibylle Dames, Maria Sternberger, Joerg Kaufmann, Anke Klippel, Differential regulation of TGF-β signaling through Smad2, Smad3 and Smad4 Oncogene. ,vol. 22, pp. 6748- 6763 ,(2003) , 10.1038/SJ.ONC.1206791
Osamu Tetsu, Frank McCormick, Proliferation of cancer cells despite CDK2 inhibition Cancer Cell. ,vol. 3, pp. 233- 245 ,(2003) , 10.1016/S1535-6108(03)00053-9