Carcinogen 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis is accelerated in Smad3 heterozygous mice compared to Smad3 wild type mice.
作者： Zhengxue Liu , Tanima Kundu-Roy , Isao Matsuura , Guannan Wang , Yong Lin
DOI: 10.18632/ONCOTARGET.11713
关键词:
摘要: Previous studies based on cell culture and xenograft animal models suggest that Smad3 has tumor suppressor function for breast cancer during early stages of tumorigenesis. In this report, we show DMBA (7,12-dimethylbenz[a]anthracene), a chemical carcinogen, induces mammary formation at significantly higher frequency in the heterozygous mice than wild type mice. This is first genetic evidence showing inhibits mouse model. Our findings support notion important cancer.
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