Albumin-deficient rat mutant
作者： S Nagase , K Shimamune , S Shumiya
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摘要: An analbuminemic colony was established from Sprague-Dawley rats. Analbuminemia inherited as an autosomal recessive trait. The rates of growth and reproduction the mutant rats were no different those normal Biochemically, characterized by extraordinarily low serum albumin content a hyperlipidemia. Total protein in rat similar to that control rats, with increased globulin. Serum cholesterol inversely correlated decrease albumin; correlation coefficient for ablumin --.92. These may serve model human familial analbuminemia also be useful elucidating functional roles albumin.
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P. Grabar, C.A. Williams, Méthode permettant l'étude conjuguée des propriétés électrophorétiques et immunochimiques d'un mélange de protéines. Application au sérum sanguin Biochimica et Biophysica Acta. ,vol. 10, pp. 193- 194 ,(1953) , 10.1016/0006-3002(53)90233-9
Edward J. Cormode, Donald M. Lyster, Sydney Israels, Analbuminemia in a neonate The Journal of Pediatrics. ,vol. 86, pp. 862- 867 ,(1975) , 10.1016/S0022-3476(75)80215-0
H. Boman, M. Hermodson, C. A. Hammond, A. G. Motulsky, Analbuminemia in an American Indian girl Clinical Genetics. ,vol. 9, pp. 513- 526 ,(2008) , 10.1111/J.1399-0004.1976.TB01606.X
T. C. Huang, C. P. Chen, Verna. Wefler, Alan. Raftery, A Stable Reagent for the Liebermann-Burchard Reaction. Application to Rapid Serum Cholesterol Determination Analytical Chemistry. ,vol. 33, pp. 1405- 1407 ,(1961) , 10.1021/AC60178A040
Keller H, Morell A, Riva G, Noseda G, Analbuminemia. Pathophysiological study of a case Schweizerische Medizinische Wochenschrift. ,vol. 102, pp. 33- 41 ,(1972)
Sauger F, Goulé Jp, Gray H, Bouillerot A, Dieryck B, Laine G, Blondet P, Maitrot B, Biochemical study on the 1st case of analbuminemia in France Annales De Biologie Clinique. ,vol. 34, pp. 403- 409 ,(1976)
Yasuhiro Hattori, Hiroaki Numata, Katsuhiro Shibata, Lipid metabolism in hyperlipemic rats Japanese Journal of Pharmacology. ,vol. 27, pp. 96- ,(1977) , 10.1016/S0021-5198(19)66504-2