Experimental and Pharmacokinetic Studies in Intraperitoneal Chemotherapy: From Laboratory Bench to Bedside

摘要: Extrapolation of experimental results to clinical practice should be done very carefully, because the differences between conditions on laboratory bench and those in human body. In setting, circumstances are much more complicated drug activity is moderated by many physiological factors. On other hand, possibility creating standardized may great help for interpretation treatment efficacy since inter-individual encumber this process. Furthermore, studies provide indicative information that valuable it practically impossible study each parameter comparative studies. The relatively small number patients available intraperitoneal chemotherapy trials complicates evaluation optimal treatment.