Effects of fenvalerate and esfenvalerate on hepatic gap junctional intercellular communication in rats
作者： Seiichi Ito , Chise Tateno , Mina Tanaka , Akira Yoshitake
DOI: 10.1007/BF00757580
关键词:
摘要: Effects of in vivo exposure with fenvalerate, esfenvalerate andDDT on hepatic gap junctional intercellular communication (GJIC) Sprague-Dawley (SD) rats were examined by vivolin vitro dye-transfer assay and immunohistochemical staining connexin 32 (C×32, major liver junction protein). Fenvalerate (75 mg/kg/day), (25 DDT (50 mg/kg/day) corn oil (vehicle control, 5mllkglday) administered orally once a day. Animals killed at weeks 1, 2, 4 6 after starting the experiment. In fenvalerate- esfenvalerate-groups, no compound-related changes GJIC C×32 expression observed. On contrary, DDT-group, average sizes dye spread injection Lucifer Yellow decreased 2 4, area per GJ spot shown C×32-immunohistochemical 6. It is concluded that neither fenvalerate nor inhibits exposure.
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sci-hub.se 参考文章(18)
Kunio SHIBA, Hideo KANEKO, Noriko KAKUTA, Akira YOSHITAKE, Junshi MIYAMOTO, Esfenvalerate および fenvalerate の妊娠ラットにおける胎盤透過性 Journal of Pesticide Science. ,vol. 15, pp. 169- 174 ,(1990) , 10.1584/JPESTICS.15.169
Hideo OHKAWA, Hideo KANEKO, Hideko TSUJI, Junshi MIYAMOTO, フェンバレレート(スミサイジン^[○!R])のラットにおける代謝 Journal of Pesticide Science. ,vol. 4, pp. 143- 155 ,(1979) , 10.1584/JPESTICS.4.143
Sten Flodstr�m, Lars W�rng�rd, Siv Ljungquist, Ulf G. Ahlborg, Inhibition of metabolic cooperation in vitro and enhancement of enzyme altered foci incidence in rat liver by the pyrethroid insecticide fenvalerate. Archives of Toxicology. ,vol. 61, pp. 218- 223 ,(1988) , 10.1007/BF00316637
Mathieu Pluijmen, Cecile Drevon, Ruggero Montesano, Christian Malaveille, Agnés Hautefeuille, Helmut Bartsch, Lack of mutagenicity of synthetic pyrethroids in Salmonella typhimurium strains and in V79 Chinese hamster cells. Mutation Research\/genetic Toxicology. ,vol. 137, pp. 7- 15 ,(1984) , 10.1016/0165-1218(84)90106-X
G.M. Williams, Liver carcinogenesis: the role for some chemicals of an epigenetic mechanism of liver-tumour promotion involving modification of the cell membrane. Food and Cosmetics Toxicology. ,vol. 19, pp. 577- 583 ,(1981) , 10.1016/0015-6264(81)90508-3
Marc Mesnil, D. James Fitzgerald, Hiroshi Yamasaki, Phenobarbital specifically reduces gap junction protein mRNA level in rat liver. Molecular Carcinogenesis. ,vol. 1, pp. 79- 81 ,(1988) , 10.1002/MC.2940010202
R.H. Bishara, G.S. Born, J.E. Christian, Radiotracer Distribution and Excretion Study of Chlorophenothane in Rats Journal of Pharmaceutical Sciences. ,vol. 61, pp. 1912- 1916 ,(1972) , 10.1002/JPS.2600611206
Shigeyuki Sugie, Hideki Mori, Masayoshi Takahashi, Effect of in vivo exposure to the liver tumor promoters phenobarbital or DDT on the gap junctions of rat hepatocytes: a quantitative freeze-fracture analysis Carcinogenesis. ,vol. 8, pp. 45- 51 ,(1987) , 10.1093/CARCIN/8.1.45
J.R.P. Cabral, D. Galendo, Carcinogenicity study of the pesticide fenvalerate in mice. Cancer Letters. ,vol. 49, pp. 13- 18 ,(1990) , 10.1016/0304-3835(90)90133-I
A. Hagiwara, M. Yamada, R. Hasegawa, S. Fukushima, N. Ito, Lack of enhancing effects of fenvalerate and esfenvalerate on induction of preneoplastic glutathione S-transferase placental form positive liver cell foci in rats. Cancer Letters. ,vol. 54, pp. 67- 73 ,(1990) , 10.1016/0304-3835(90)90093-D