Numerical study of fibre deposition in a human nasal cavity

作者: Kiao Inthavong , Jian Wen , Zhaofeng Tian , Jiyuan Tu

DOI: 10.1016/J.JAEROSCI.2007.11.007

关键词:

摘要: Abstract The inhalation of toxic particles such as asbestos fibres through the nasal airway has been found to cause harmful damage respiratory system. This study made use CFD techniques investigate deposition fibrous in a human cavity. A 3D computational model was created from CT scans which provided framework flow and at constant rate 7.5 L/min. effects fibres’ elongated shape, density size were incorporated into empirical drag correlations fibre trajectories recorded Lagrangian tracking scheme. In general, good agreement right cavity an overprediction left major differences geometrical variations between subjects well cavities. dominant mechanism by inertial impaction, with majority depositing anterior region. It that had very low deposition, ≈ 14 % , independent length. comparison, carbon exhibited increases length increased. parameter ρ cross represents mass per unit used equate d ae for different lengths.

参考文章(23)
John R. Grace, R. Clift, Martin E. Weber, Bubbles, Drops, and Particles ,(1978)
Ravi.P. Subramaniam, Regina.B. Richardson, Kevin.T. Morgan, Julia.S. Kimbell, Raymond.A. Guilmette, COMPUTATIONAL FLUID DYNAMICS SIMULATIONS OF INSPIRATORY AIRFLOW IN THE HUMAN NOSE AND NASOPHARYNX Inhalation Toxicology. ,vol. 10, pp. 91- 120 ,(1998) , 10.1080/089583798197772
I. Hahn, P. W. Scherer, M. M. Mozell, Velocity profiles measured for airflow through a large-scale model of the human nasal cavity Journal of Applied Physiology. ,vol. 75, pp. 2273- 2287 ,(1993) , 10.1152/JAPPL.1993.75.5.2273
A. Haider, O. Levenspiel, Drag coefficient and terminal velocity of spherical and nonspherical particles Powder Technology. ,vol. 58, pp. 63- 70 ,(1989) , 10.1016/0032-5910(89)80008-7
Michaela Kreuzer, Klaus M. Müller, Annemarie Brachner, Michael Gerken, Bernd Grosche, Thorsten Wiethege, H.-Erich Wichmann, Histopathologic findings of lung carcinoma in German uranium miners Cancer. ,vol. 89, pp. 2613- 2621 ,(2000) , 10.1002/1097-0142(20001215)89:12<2613::AID-CNCR14>3.0.CO;2-Y
V. Timbrell, DEPOSITION AND RETENTION OF FIBRES IN THE HUMAN LUNG Annals of Occupational Hygiene. ,vol. 26, pp. 347- 369 ,(1982) , 10.1093/ANNHYG/26.2.347
K. Inthavong, Z. F. Tian, H. F. Li, J. Y. Tu, W. Yang, C. L. Xue, C. G. Li, A Numerical Study of Spray Particle Deposition in a Human Nasal Cavity Aerosol Science and Technology. ,vol. 40, pp. 1034- 1045 ,(2006) , 10.1080/02786820600924978
Hakon Wadell, Sphericity and Roundness of Rock Particles The Journal of Geology. ,vol. 41, pp. 310- 331 ,(1933) , 10.1086/624040
M. Finck, D. Hänel, I. Wlokas, Simulation of nasal flow by lattice Boltzmann methods Computers in Biology and Medicine. ,vol. 37, pp. 739- 749 ,(2007) , 10.1016/J.COMPBIOMED.2006.06.013
M Lippmann, Effects of fiber characteristics on lung deposition, retention, and disease. Environmental Health Perspectives. ,vol. 88, pp. 311- 317 ,(1990) , 10.1289/EHP.9088311