Protocolized fluid therapy in brain-dead donors: the multicenter randomized MOnIToR trial

作者: Ali Al-Khafaji , Michele Elder , Daniel J. Lebovitz , Raghavan Murugan , Michael Souter

DOI: 10.1007/S00134-014-3621-0

关键词:

摘要: Background Critical shortages of organs for transplantation jeopardize many lives. Observational data suggest that better fluid management deceased organ donors could increase recovery. We conducted the first large multicenter randomized trial in brain-dead to determine whether protocolized therapy increases number transplanted.

参考文章(31)
P. L. Abt, C. L. Marsh, T. B. Dunn, W. R. Hewitt, J. R. Rodrigue, J. M. Ham, S. Feng, Challenges to Research and Innovation to Optimize Deceased Donor Organ Quality and Quantity American Journal of Transplantation. ,vol. 13, pp. 1400- 1404 ,(2013) , 10.1111/AJT.12243
E. E. Messersmith, C. Arrington, C. Alexander, J. P. Orlowski, R. Wolfe, Development of Donor Yield Models American Journal of Transplantation. ,vol. 11, pp. 2075- 2084 ,(2011) , 10.1111/J.1600-6143.2011.03639.X
A. K. Israni, D. A. Zaun, J. D. Rosendale, J. J. Snyder, B. L. Kasiske, OPTN/SRTR 2011 Annual Data Report: Deceased Organ Donation American Journal of Transplantation. ,vol. 13, pp. 179- 198 ,(2013) , 10.1111/AJT.12025
Ali Salim, George C. Velmahos, Carlos Brown, Howard Belzberg, Demetrios Demetriades, Aggressive organ donor management significantly increases the number of organs available for transplantation. Journal of Trauma-injury Infection and Critical Care. ,vol. 58, pp. 991- 994 ,(2005) , 10.1097/01.TA.0000168708.78049.32
Peter S. Macdonald, Anders Aneman, Deepak Bhonagiri, Daryl Jones, Gerry O’Callaghan, William Silvester, Alasdair Watson, Geoffrey Dobb, A systematic review and meta-analysis of clinical trials of thyroid hormone administration to brain dead potential organ donors* Critical Care Medicine. ,vol. 40, pp. 1635- 1644 ,(2012) , 10.1097/CCM.0B013E3182416EE7
Raghavan Murugan, Ramesh Venkataraman, Abdus S Wahed, Michele Elder, Georgene Hergenroeder, Melinda Carter, Nicholas J Madden, David Powner, John A Kellum, HIDonOR Study Investigators, Increased plasma interleukin-6 in donors is associated with lower recipient hospital-free survival after cadaveric organ transplantation. Critical Care Medicine. ,vol. 36, pp. 1810- 1816 ,(2008) , 10.1097/CCM.0B013E318174D89F
George S. Dikdan, Cesar Mora-Esteves, Baburao Koneru, Review of randomized clinical trials of donor management and organ preservation in deceased donors: opportunities and issues. Transplantation. ,vol. 94, pp. 425- 441 ,(2012) , 10.1097/TP.0B013E3182547537
Antti Kämäräinen, Ilkka Virkkunen, Jyrki Tenhunen, Hypothermic preconditioning of donor organs prior to harvesting and ischaemia using ice-cold intravenous fluids Medical Hypotheses. ,vol. 73, pp. 65- 66 ,(2009) , 10.1016/J.MEHY.2009.01.037
Raghavan Murugan, Ramesh Venkataraman, Abdus S Wahed, Michele Elder, Melinda Carter, Nicholas J Madden, John A Kellum, HIDonOR Study Investigators, Preload responsiveness is associated with increased interleukin-6 and lower organ yield from brain-dead donors. Critical Care Medicine. ,vol. 37, pp. 2387- 2393 ,(2009) , 10.1097/CCM.0B013E3181A960D6
Michael M. Rey, Lorraine B. Ware, Michael A. Matthay, Gordon R. Bernard, Amy L. McGuire, Arthur L. Caplan, Scott D. Halpern, Informed consent in research to improve the number and quality of deceased donor organs. Critical Care Medicine. ,vol. 39, pp. 280- 283 ,(2011) , 10.1097/CCM.0B013E3181FEEB04