Androgen and androgen-metabolizing enzymes in metastasized lymph nodes of breast cancer

摘要: Androgen receptor and androgen metabolizing enzymes, 17β-hydroxysteroid dehydrogenase type 5 (17βHSD5) 5α-reductase1 (5α1), are frequently detected in primary tumor of breast cancer, but their status metastatic lymph nodes has not been examined. The biological role cancer its process also remain unknown. In this study, we used immunohistochemistry to localize the expression receptor, 17βHSD5, 5α1 tumors paired correlated findings with clinicopathologic factors individual patients. Approximately 70% expressed significant correlation between both lesions. However, 17βHSD5 immunoreactivity was decreased nodes. Alone or tandem associated significantly lower Ki-67 index, pathologic grade, higher estrogen positivity, receptor/5α1 double positivity larger node metastasis TNM stage. conclusion, remained stable during metastasis, whereas androgen-metabolizing enzymes decreased. Although results our study previous reports imply additional roles metabolism process, especially conversion by 5α1, there may be divergence effects on those