T-cadherin, a novel cadherin cell adhesion molecule in the nervous system lacks the conserved cytoplasmic region.
作者： Barbara Ranscht , Maria T. Dours-Zimmermann
DOI: 10.1016/0896-6273(91)90291-7
关键词:
摘要: Abstract We have characterized T-cadherin, a glycoprotein of 95 kd from chick embryo brain by expression cloning and sequencing corresponding cDNAs. The nucleotide sequence predicts novel cadherin cell adhesion molecule in the nervous system. Surprisingly, isolated cDNAs do not encode cytoplasmic region conserved other subclasses. Biochemical analysis revealed that this truncated (T) is attached to neuronal plasma membrane through glycosyl phosphatidylinositol anchor. T-cadherin component different populations expressed temporally spatially restricted pattern during axon growth. These results are consistant with putative role growth guidance.
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