The Uvomorulin—Catenin Complex

作者: Martin Ringwald

DOI: 10.1007/978-1-4615-2466-3_5

关键词: CadherinMorphogenesisCell adhesion moleculeCatenin complexCell sortingFunction (biology)Cell biologyAdhesionAdherens junctionChemistry

摘要: Cadherins are a protein family of Ca2+-dependent transmembrane-type cell adhesion molecules. They mediate cell-cell by homophilic binding. All solid tissues in vertebrates express some Cadherins. Very importantly for their function, the different Cadherin subtypes show distinct developmental and tissue-specific patterns expression display corresponding binding specificities. In this way, thought to influence sorting, morphogenesis, maintenance adult (Takeichi, 1988, 1991; Kemler et al., 1989).

参考文章(71)
S. Eidelman, M. J. Wheelock, C. H. Damsky, I. Damjanov, Expression of the cell-cell adhesion glycoprotein cell-CAM 120/80 in normal human tissues and tumors. American Journal of Pathology. ,vol. 135, pp. 101- 110 ,(1989)
A.E. Parker, G.N. Wheeler, J. Arnemann, S.C. Pidsley, P. Ataliotis, C.L. Thomas, D.A. Rees, A.I. Magee, R.S. Buxton, Desmosomal glycoproteins II and III. Cadherin-like junctional molecules generated by alternative splicing. Journal of Biological Chemistry. ,vol. 266, pp. 10438- 10445 ,(1991) , 10.1016/S0021-9258(18)99244-6
Setsuo Hirohashi, Yutaka Shimoyama, Expression of E- and P-cadherin in gastric carcinomas. Cancer Research. ,vol. 51, pp. 2185- 2192 ,(1991)
E.M. Shore, W.J. Nelson, Biosynthesis of the cell adhesion molecule uvomorulin (E-cadherin) in Madin-Darby canine kidney epithelial cells. Journal of Biological Chemistry. ,vol. 266, pp. 19672- 19680 ,(1991) , 10.1016/S0021-9258(18)55045-6
M. Ringwald, R. Schuh, D. Vestweber, H. Eistetter, F. Lottspeich, J. Engel, R. Dölz, F. Jähnig, J. Epplen, S. Mayer, The structure of cell adhesion molecule uvomorulin. Insights into the molecular mechanism of Ca2+-dependent cell adhesion. The EMBO Journal. ,vol. 6, pp. 3647- 3653 ,(1987) , 10.1002/J.1460-2075.1987.TB02697.X
François Hyafil, Dominique Morello, Charles Babinet, François Jacob, A cell surface glycoprotein involved in the compaction of embryonal carcinoma cells and cleavage stage embryos Cell. ,vol. 21, pp. 927- 934 ,(1980) , 10.1016/0092-8674(80)90456-0
A.M. Belkin, V.E. Koteliansky, Interaction of iodinated vinculin, metavinculin and α-actinin with cytoskeletal proteins FEBS Letters. ,vol. 220, pp. 291- 294 ,(1987) , 10.1016/0014-5793(87)80832-3
W. W. Franke, M. D. Goldschmidt, R. Zimbelmann, H. M. Mueller, D. L. Schiller, P. Cowin, Molecular cloning and amino acid sequence of human plakoglobin, the common junctional plaque protein. Proceedings of the National Academy of Sciences. ,vol. 86, pp. 4027- 4031 ,(1989) , 10.1073/PNAS.86.11.4027