The genetics of murine leukemia viruses

作者: S. P. Goff

DOI: 10.1007/978-3-642-69677-0_3

关键词:

摘要: The murine leukemia viruses are prototypical replication-competent retroviruses. These were among the first known oncogenic agents in mammals and have been subjects of intensive study for more than 3 decades (Gross 1970). We now a detailed understanding life cycle these some genetic effects they can on host cell; we even beginning to discover how cause leukemia. Today, remain popular systems gene transfer expression, site-specific recombination mammalian cells, mutagenesis, processes induction progression tumors. Most recently, their similarity human T-cell (HTLVs) (Poiesz et al. 1982) sequences endogenous genome (Repaske 1983) has stimulated interest still larger scientific community.

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