Glucocorticoid receptor gene-based SNP analysis in patients with recurrent major depression
作者： Dirk van West , Filip Van Den Eede , Jurgen Del-Favero , Daniel Souery , Karl-Fredrik Norrback
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摘要: Dysregulation of the hypothalamic-pituitary-adrenal axis, one stress-response systems, is key neurobiological features major depression (MDD). Data supporting notion that glucocorticoid-mediated feedback inhibition impaired in MDD come from a multitude studies demonstrating nonsuppression cortisol secretion following administration synthetic glucocorticoid dexamethasone. We examined whether genetic variations receptor gene (Nuclear Receptor Subfamily 3, Group C, Member 1; NR3C1) could be associated with increased susceptibility for using whole gene-based association analysis single nucleotide polymorphisms (SNPs). Four SNPs were identified NR3C1 and genotyped two well-diagnosed samples patients ascertained Belgium northern Sweden, matched control samples. In total, 314 354 individuals included study. Belgian sample, we observed significant allele (p=0.02) genotype an SNP promoter region (NR3C1-1); Swedish R23K SNP. The haplotype showed modest evidence involvement 5' vulnerability MDD. This study suggests may play role
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