P3HT:Bebq2-Based Photovoltaic Device Enhances Differentiation of hiPSC-Derived Retinal Ganglion Cells.

摘要: Electric field stimulation is known to affect various cellular processes, including cell fate specification and differentiation, particularly towards neuronal lineages. This makes it a promising therapeutic strategy stimulate regeneration of tissues. Retinal ganglion cells (RGCs) type neural the retina responsible for transduction visual signals from brain cortex, often degenerated in blindness-causing retinal diseases. The organic photovoltaic materials such as poly-3-hexylthiophene (P3HT) can generate electric current upon illumination with light visible spectrum, possesses several advantageous properties, weight, flexibility high biocompatibility, which them highly tool vitro vivo. In this study, we tested ability photocurrent by formulations blend (bulk heterojunction) P3HT (which electron donor material) acceptor materials, Alq3 bis(10-hydroxybenzo[h]quinolinato)beryllium (Bebq2). We found that device based on bulk heterojunction Bebq2 could when illuminated both green laser spectrum light. growth differentiation capacity human induced pluripotent stem (hiPSC)-derived RGCs grown interface photostimulated device, they were significantly increased. application P3HT:Bebq2-formulation has great potential developments transplantation, nerve repair tissue engineering approaches treatment degeneration.