Septal grafts improve acquisition of an operant timing task after fimbria-fornix lesions in rats: Role of the interval between lesion and transplantation surgeries.

摘要: In a previous study we evaluated the conditions under which septal grafts could ameliorate performance of rats with fimbria-fornix lesions in an operant differential reinforcement low rates responding (DRL) task. Although best recovery was demonstrated by group were made 10 days following lesion surgery, this factor (lesion-graft interval) confounded developmental stage donor tissue, and it suggested that age embryonic more significant than graft interval achieving good recovery. The present provides better control tissues, report cholinergic rich implanted into host hippocampus either immediately or 11 yielded when after longer (8 weeks) lesion-graft intervals. addition, intact without effect subjected to delayed weeks implantation. These results corroborate hypothesis Nieto-Sampedro, Manthorpe colleagues 'wound-derived neurotrophic factors' can promote functional viability hippocampus, even if such factors are not absolutely necessary for survival.