Risk of cardiovascular events among women with high normal blood pressure or blood pressure progression: prospective cohort study

摘要: Objective To compare cardiovascular risk among women with high normal blood pressure (130-9/85-9 mm Hg) against those (120-9/75-84 and baseline hypertension. Design Prospective cohort study. Setting Women9s health study, United States. Participants 39 322 initially healthy classified into four categories according to self reported followed for a median of 10.2 years. Main outcome measures Time death, myocardial infarction, or stroke (major event—primary end point); progression Results 982 (2.5%) developed major event, 8686 (30.1%) without hypertension progressed The age adjusted event rate the primary point was 1.6/1000 person years pressure, 2.9/1000 4.3/1000 Compared (reference group), had lower (adjusted hazard ratio 0.61, 95% confidence interval 0.48 0.76) incident (0.42, 0.40 0.44). in 1.30 (1.08 1.57). Women who group) during first 48 months study higher than remained normotensive 0.64, 0.50 0.81). at similar rates 1.17, 0.88 1.55). Conclusion is that pressure. progress increased shortly after diagnosis has been made. Trial registration Clinical trials NCT00000479.