Emerging Roles of Brain-Specific Angiogenesis Inhibitor 1
作者： Daeho Park , Kodi S. Ravichandran
DOI: 10.1007/978-1-4419-7913-1_15
关键词:
摘要: Brain-specific angiogenesis inhibitor 1 (BAI1) encodes a seven-transmembrane protein that belongs to the adhesion-GPCR family.1, 2, 3, 4, 5, 6, 7 Although BAI1 was named for ability of its extracellular region inhibit in tumor models, function physiological contexts elusive and remained an orphan receptor until recently.5,6,8, 9, 10, 11, 12, 13, 14 is now considered phagocytic can recognize phosphatidylserine exposed on apoptotic cells. Moreover, has been shown upstream signaling module comprised ELMO/Dock180/Rac proteins, thereby facilitating cytoskeletal reorganization necessary mediate clearance cells.15,16 Here,wereview phytogeny, structure, associating as well known proposed functions BAI1.
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