The Extent and Severity of Vascular Leakage as Evidence of Tumor Aggressiveness in High-Grade Gliomas

摘要: Magnetic resonance imaging reveals heterogeneous regions within high-grade gliomas, such as a contrast-enhanced rim, necrotic core, and non-contrast-enhanced abnormalities. It is unclear which of these best describes tumor aggressiveness. We hypothesized that the vascular leakage volume, reflecting disorganized angiogenesis typical glioblastoma, would be strong predictor clinical outcome. The FLAIR post-gadolinium T1 volume determined by dynamic imaging, rim seen on T1-weighted images were defined for 20 patients about to undergo treatment newly diagnosed gliomas. potential characteristics improve prediction survival time progression over variables was tested using Cox regression analysis. Single-variable analysis each four subvolumes revealed only significant survival. When joint effect survival, age selected predictors. However, when dependent variable, both permeability copredictors, along with surgical status. Our findings suggest glioma, after radiation therapy influenced underlying biological aggressiveness (vascularity) aggressive tumor. In contrast, depends chiefly at presentation.