L-(methyl-11C) methionine positron emission tomography for target delineation in resected high-grade gliomas before radiotherapy.

摘要: Purpose: Using magnetic resonance imaging (MRI), residual tumor cannot be differentiated from nonspecific postoperative changes in operated patients with brain gliomas. The higher specificity and sensitivity of l-(methyl-11C)-labeled methionine positron emissions tomography (MET-PET) gliomas has been demonstrated previous studies is the rationale for integration this investigation gross volume delineation. goal trial was to quantify affect MET-PET vs. MRI definition radiotherapy planning high-grade Methods Materials: included 39 resected malignant data were coregistered based on mutual information. tissue abnormalities T 1 -weighted (gadolinium [Gd] enhancement) 2 (hyperintensity areas) compared using MET-PET/MRI fusion images. Results: Gd-enhanced analysis performed patients. In 5 (13%), MET uptake corresponded exactly Gd enhancement, 29 (74%) patients, region larger than that enhancement. 27 (69%) enhancement area extended beyond detected up 45 mm investigated 18 did not correspond hyperintensity areas any patient. 9 (50%) MRI, (100%), at least some located outside area. 40 MRI. Conclusion: gliomas, size location differs considerably found Because by MET-PET, a greater tissue, can help outline accuracy.