Biology is the root of variability: cautionary tales in Caenorhabditis elegans biology.

摘要: Reproducibility is critical for the standardization, interpretation, and progression of research. However, many factors increase variability reduce reproducibility. In Caenorhabditis elegans research, there are possible causes that may explain why experimental outcomes sometimes differ between laboratories experiments. Factors contributing to include genetic background both C. its bacterial diet, differences in media composition, intergenerational transgenerational effects be carried over generations, use chemicals or reagents have unexpected consequences. This review summarizes sources research serves identify laboratory practices could influence