Identification and validation of a hub gene prognostic index for hepatocellular carcinoma.
作者： Y F Wang , W H Wang , Q Shi , X X Tian , Z Meng
关键词:
摘要: Aims: We aim to provide new insights into the mechanisms of hepatocellular carcinoma (HCC) and identify key genes as biomarkers for prognosis HCC. Materials & methods: Differentially expressed between HCC tissues normal were identified via Gene Expression Omnibus tool. The top ten hub screened by degree protein nodes in protein-protein interaction network also showed significant associations with overall survival patients. Results: A prognostic model containing a five-gene signature was constructed predict multivariate Cox regression analysis. Conclusion: This study novel (CDK1, CCNB1, CCNB2, BUB1 KIF11) independent factor.
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