Effects of the local anesthetics brufacain and lidocaine on transmembrane action potentials, refractory period, and reactivation of the sodium system in guinea pig heart muscle.
作者： H. Iven , H. Brasch
DOI: 10.1007/BF00499925
关键词:
摘要: Lidocaine (3 · 10−5 and 10−4 M) equimolar concentrations of brufacian dose-dependently reduced the depolarization velocity (dV/dtmax) force contraction guinea pig atria papillary muscles. Repolarization time was increased in but The maximum effects on action potential parameters were identical developed with brufacain more slowly than lidocaine.
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sci-hub.se 参考文章(27)
L. Szekeres, Gy J. Papp, Experimental Cardiac Arrhythmias and Antiarrhythmic Drugs ,(1971)
D. Burhorn, C.-P. Siegers, K.-W. Diederich, Beziehungen zwischen antiarrhythmischer Wirkung und pharmakologischen Daten von Brufacain® bei parenteraler und oraler Anwendung am Menschen J.F. Bergmann-Verlag, Munich. pp. 187- 190 ,(1975) , 10.1007/978-3-642-85450-7_32
E. Carmeliet, R. Xhonneux, Influence of lidoflazine on cardiac transmembrane potentials and experimental arrhythmias. Naunyn-Schmiedebergs Archiv f�r Pharmakologie. ,vol. 268, pp. 210- 228 ,(1971) , 10.1007/BF01020076
W. Trautwein, J. Dudel, Zum Mechanismus der Membranwirkung des Acetylcholin an der Herzmuskelfaser Pflügers Archiv: European Journal of Physiology. ,vol. 266, pp. 324- 334 ,(1958) , 10.1007/BF00416781
B I Sasyniuk, R I Ogilvie, Antiarrhythmic drugs: electrophysiological and pharmacokinetic considerations. Annual Review of Pharmacology. ,vol. 15, pp. 131- 155 ,(1975) , 10.1146/ANNUREV.PA.15.040175.001023
Luc M. Hondeghem, Augustus O. Grant, Richard A. Jensen, Antiarrhythmic drug action: Selective depression of hypoxic cardiac cells American Heart Journal. ,vol. 87, pp. 602- 605 ,(1974) , 10.1016/0002-8703(74)90498-0
B. N. Singh, E. M. Vaughan Williams, Effect of Altering Potassium Concentration on the Action of Lidocaine and Diphenylhydantoin on Rabbit Atrial and Ventricular Muscle Circulation Research. ,vol. 29, pp. 286- 295 ,(1971) , 10.1161/01.RES.29.3.286
H. Tritthart, B. Fleckenstein, A. Fleckenstein, Some fundamental actions of antiarrhythmic drugs on the excitability and the contractility of single myocardial fibers Naunyn-Schmiedebergs Archiv f�r Pharmakologie. ,vol. 269, pp. 212- 219 ,(1971) , 10.1007/BF01003038
G. Zetler, O. Strubelt, Actions of antiarrhythmic drugs on refractory period and contractility of isolated rat and guinea-pig atria. Naunyn-Schmiedebergs Archiv f�r Pharmakologie. ,vol. 271, pp. 335- 345 ,(1971) , 10.1007/BF00997123
H. Iven, G. Zetler, The effects of harmine on the transmembrane action potentials of guinea-pig left atria as compared to those of quinidine Naunyn-schmiedebergs Archives of Pharmacology. ,vol. 283, pp. 181- 189 ,(1974) , 10.1007/BF00501144