Clinical features and EEG findings differentiating mesial from neocortical temporal lobe epilepsy

摘要: We evaluated whether mesial temporal lobe epilepsy (MTE) and neocortical (NTE) can be distinguished on electroclinical grounds. One hundred twenty-two consecutive MTE (n = 86) NTE 36) patients were included in this prospective study. All underwent prolonged EEG-video monitoring high resolution magnetic-resonance imaging (MRI). was defined as with purely lesion the absence of extramesial pathology, based pre-operative MRI or post-operative histology. lesions, depth recorded seizure onset lack lesions thousand two fourty-nine epileptic seizures analyzed. Congenital malformation (NTE 19% versus 3%, P 67%) over ipsilateral regions (MTE 65% 33%, < 0.001). No patient had lateral spike predominance 22%, Multiple logistic regression revealed that a history febrile seizures, abdominal auras, contralateral dystonic posturing spikes point to MTE, an accuracy 73% (PPV 81%, NPV 70%). Analyzing clinical EEG features, particularly distribution interictal epileptiform discharges, helps differentiate between NTE.