Multiple Transmitter Receptors in Regions and Layers of the Human Cerebral Cortex.

摘要: We measured the densities (fmol/mg protein) of 15 different receptors various transmitter systems in supragranular, granular and infragranular strata 44 areas visual, somatosensory, auditory multimodal association human cerebral cortex. Receptor were obtained after labeling using quantitative vitro receptor autoradiography postmortem brains. The mean density each type over all cortical layers three major varies between regions. In a single area, multi-receptor fingerprints its (i.e., polar plots, visualizing multiple types or same area) differ shape size indicating regional laminar specific balances receptors. Furthermore, are clearly segregated into well definable clusters by their fingerprints. Fingerprints systematically vary functional networks, with hierarchical levels within sensory systems. Primary separated from other particularly very high muscarinic M2 nicotinic alpha4beta2 densities, to lesser degree also noradrenergic alpha2 serotonergic 5-HT2 Early visual dorsal ventral streams results discussed on background segregation, hierarchies, microstructural types, horizontal (layers) vertical (columns) organization conclude that column is composed segments, which can be assigned strata. segments patterns balances, layer-specific signal processing mechanisms. Additionally, differences strata-and area-specific reflect segregation cortex functionally topographically groups (visual, auditory, limbic, motor), reveals position (primary unimodal (early) higher finally areas).