摘要: In 1983, at the National Naval Medical Center (Bethesda, Maryland), I consulted on a patient who had metastatic colon cancer. He received chemotherapy with 5-fluorouracil and methotrexate two half months one month before conception again around time of pregnancy. fourth pregnancy, obstetricians asked for genetic advice about this couple. The man’s history was also unusual because his father died lymphoma, ureteral transitional cell carcinoma occurred in brother paternal cousins. Ultrasound examination fetus amniocentesis were recommended to monitor found have deletion long arm chromosome 1. Was chromosomal defect due exposure germ cells chemotherapy? circumstances might support such conclusion but mother same minor clinically normal; hence, called normal variant family. A baby born, six weeks after father’s death.
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